Malaria originated in Africa and is caused by an infection with the plasmodium protozoan. Five types have infected humans; Plasmodium falciparum is the most lethal and is responsible for the vast majority of global malaria deaths. ‘Malaria’ outlines the spread of malaria from Africa, into Europe and the New World. Generally, agricultural and rural development has been responsible for the proliferation of malaria, but poor sanitation and stagnant water can make malaria an urban disease. Vector and parasite control is described, along with the World Health Organization’s Malaria Eradication Program and attempts to stem malaria with treated bed nets and more effective drugs.