The challenges we face for near and long-term futures have been called a crisis of crises. ‘Grand global futures challenges’ synthesizes these complex and interconnected major global futures challenges into twelve clusters of issues across three domains: environmental, geo-political, and socio-cultural. The first mind-map includes current trends likely to create major problems for futures of humanity. The second includes counter-trends, twists, and surprises. These alternative futures have potential to mitigate, disrupt, or reverse the dominant trends and enable others to imagine and create alternatives to the disturbing trends being forecast. Finally, the focus is on three Grand Global Challenges: growing urbanization, lack of (or inadequate) education, and the climate crisis.