Why is there a relation between handedness and the cerebral hemisphere that is specialized for language? How is it that we can learn the violin? Why can’t we tickle ourselves? ‘Acting’ considers these questions and in doing so, looks at right-handedness, left hemisphere specialization for gestures, spoken language, learning skills, and the sensory consequences of actions. There is a relation between right-handedness and left hemisphere dominance for speech. It is likely that in human evolution the tendency to right-handedness developed before speech. Both vocal and manual skills depend on cerebellar mechanisms, and in the human brain the cerebellum has expanded in line with the neocortex.