‘What to do with a psychopath?’ outlines some pertinent questions and the evidence regarding treatment and prevention of psychopathy. Is it possible to treat adults with psychopathy or prevent psychopathy from developing? We do not currently know to what extent it is possible to change particular psychopathic traits and cognitions. Is it perhaps more realistic to find another way of ensuring that individuals with psychopathy behave in ways that do not violate the rights of others, even if they cannot be made to feel true empathy? And, should we concentrate more effort on prevention and intervention work in childhood and adolescence? Areas for future research are discussed.