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p. 525. Testing how to control a diseaselocked

  • Rodolfo Saracci

Abstract

‘Testing how to control a disease’ lists key features of randomized controlled trials: the study design is always based on randomization; the choice of the study population is critical for generalizing the conclusions drawn from a trial; the treatment can be as simple as a drug or a vaccine or more complex, such as an intervention to modify the habitual diet; usually several responses to the treatment or endpoints will be assessed to measure intended and possible adverse effects of the treatment; the analysis of the data collected during the study is done at the end. Often, however, some intermediate analyses can be done to monitor what is happening.

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