Some people believe depression is massively over-diagnosed, some believe it to be an understandable reaction to life that should not be medicalized or treated, and some view depression as a diagnosable disorder but disagree with the treatments that should be offered. Is depression over-diagnosed? Do antidepressants work? Are all therapies equally effective for depression? ‘Current controversies, future directions’ explores these issues and looks at what evidence exists for the use of complementary and alternative therapies such as herbal medicines and exercise. It examines links between mood disorders and circadian rhythms and the immune system, and between research on the psychotherapy of the mind and the neuroscience of the brain.