Is there a personality conducive to genius? ‘Chameleon personalities’ considers this question by looking at personality traits. Personality is now widely tested using a ‘five-factor model’. Daniel Nettle labels these five character traits as extraversion, neuroticism, conscientiousness, agreeableness, and openness. Advances in brain imaging and human genome sequencing have provided a consensus with this model. Unfortunately for any putative ‘creative personality’, ‘openness’ is the least well analysed of the five-factor traits. The personalities of Mozart, Einstein, Vincent Van Gogh, Virginia Woolf, and Charles Darwin are discussed. The conclusion is that to be exceptionally creative means to have a chameleon personality. Exceptionally creative individuals modify their personalities to suit their context.