‘Personalized pluripotent stem cells’ looks at cloning. This connection to stem cell biology lies in the potential routes that have been sought to make personalized pluripotent stem cells that are a perfect genetic match to a specific patient, and will therefore provoke no immune rejection on grafting. Animal cloning, resulting in the creation of Dolly the sheep in 1997 using somatic cell nuclear transfer, is discussed along with therapeutic cloning, ES cell lines and induced pluripotent stem (iPS) cells. The latter are extremely similar to ES cells and are made by introducing a few specific genes into normal cells. Patient-specific iPS cell lines and personalized cell culture are also considered.