Cross-border institutions and systems are more important now than they have ever been. There are a number of issues that aren't subject to border controls: the environment, public health, the flow of information. ‘Cross-border institutions and systems’ considers how cross-border institutions and systems operate in the contemporary world. Today, ideas and information cross borders more readily than they ever have done. The ability of groups to transcend space and border barriers poses a challenge for governments. How has ‘supranationalism’ affected territorial assumptions of the nation-state system? The European Union's success in eliminating barriers between member states may ironically increase independence movements. What problems to borders pose for enforcing global human rights?